主 要 学 术 成 果:
科研项目:
1、国家自然科学基金面上项目,81373350、转运sirna的双靶向长循环多功能信封式纳米基因载体的研究、2014/01-2014/12、16万元、已结题、参加(第二)。
2、国家自然科学基金面上项目,30772000、n-3不饱和脂肪酸转基因小鼠模型的抗病性研究、2008/01-2008/12、8万元、已结题、主持。
3、国家自然科学基金面上项目,30671079、高含量n-3不饱和脂肪酸转基因小鼠模型的建立、2007/01-2007/12、8万元、已结题、主持。
4、国家自然科学基金面上项目,30370467、下丘脑神经肽信号通路第二级神经元在摄食调解中的作用、2004/01-2006/12、20万元、已结题、参加(第二)。
5、国家自然科学基金面上项目,30271217、腺病毒介导的fat-1基因抗乳腺癌研究、2003/01-2005/12、18万元、已结题、主持。
6、山东省科技发展计划,2014ggh218023、靶向载体和靶向癌基因的双靶向抗肝癌药物研究、2014/01-2015/12、50万元、在研、主持。
7、山东省自然科学基金面上项目,zr2010cm010、omega-3多不饱和脂肪酸对细胞免疫相关mirna的调控研究、2010/10-2013/10、7万元、主持。
8、山东省自然科学基金面上项目,y2002d07、腺病毒介导的fat-1基因抗神经细胞凋亡研究、2003/01-2005/12、5万元、已结题、主持。
9、教育部博士点基金,20061065003,高含量n-3不饱和脂肪酸转基因小鼠模型的建立、2007/01-2009/12、6万元、已结题、主持。
著作教材:
1. 医学分子生物学(研究生用),人民卫生出版社(国家十二五规划教材), 编委 2014.5
2. 医学分子生物学 人民卫生出版社 编委 2008.6
3. 生物化学 科学出版社 编委 2007.6
4. 生物化学(护理专业)人民卫生出版社 副主编 2006.8 5. 分子生物学 科学出版社 副主编 2008.6
6. 生物化学学习指导及习题集 人民卫生出版社 副主编 2006.8
7. biochemistry 科学出版社 编委 2009.6 8. biochemistry 吉林科技出版社 编委 2004.8
期刊论文:
1). ge yl, zhang x, zhang jy, hou l, tian rh. the mechanisms on apoptosis by inhibiting vegf expression in human breast cancer cells. int immunopharmacol, 2009 apr;9(4):389-95.
2). yin-lin ge, jin-yu zhang, xiao zhang, lin hou, quan li, mei-lan xu. chemically modified sirna directed against the kdr gene inhibits the proliferation of breast cancer cells. molecular medicine reports,2009, 2 (1): 121-127.
3).yinlin ge, zhi hongchen,zhao b. kang, joanne cluette-brown, michael laposata and jing x. kang. effects of adenoviral gene transfer of c. elegans n-3 fatty acid desaturase on the fatty acid composition and growth of human breast cancer cells in culture. anticancer research, 2002,22:537-544.
4). yinlin ge, xiaoying wang, zhihong chen, natalie landman, eng h.lo and jing x. kang. gene transfer of the caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosis. journal of neurochemistry, 2002,82(6):1360-1366.
5). yin lin ge, tohru ohta, daniel j. driscoll, robert d. nicholls, satya p. kalra. anorexigenic melanocortin signaling in the hypothalamus is augmented in association with failure-to-thrive in transgenic mouse model for prader-willi syndrome. brain research,2002,957(1):42-5.
6). wen-hui ma , yong-chao liu, mei-lan xue, zheng zheng and yin-lin ge*. downregulation of survivin expression exerts antitumoral effects on mouse breast cancer cells in vitro and in vivo. oncology letters, 2016, 11:159-167.
7). shiguo liu#, xiaoxia yu# , quanchen xu, jiajia cui, mingji yi, xinhua zhang, yinlin ge* & xu ma*. support of positive association in family-based genetic analysis between col27a1 and tourette syndrome. scientific reports,2015, | 5:12687 | doi: 10.1038/srep12687
8). zheng z, ge y*, zhang j, xue m, li q, lin d, ma w. pufa diets alter the microrna expression profiles in an inflammation rat model. mol med rep. 2015,11(6):4149-4157.
9). shiguo liu, xueqin wang, longqiang xu, lanlan zheng,yinlin ge*, xu ma. family-based association study between monoamine. neurocase,2015,21(1):106-108.
10). xiao zhang; yin-lin ge*; shu-ping zhang; ping yan; run-hua tian. down regulation of kdr expression induces apoptosis in breast cancer cells. cellular & molecular biology letters, 2014, 19(4):527-541.
11). yuanyuan zhang,junhong liu,yuanming zhou,yinlin ge*. spore production of clonostachys rosea in a new solid-state fermentation reactor. appl biochem biotechnol,2014,174(8):2951-2959.
12). yuanyuan zhang, junhong liu, yuanming zhou, tingyun gong, jing wang.yinlin ge*. enhanced phytoremediation of mixed heavy metal (mercury)–organicpollutants (trichloroethylene) with e transgenic alfalfa co-expressingglutathione s-transferase and human p450 2e1. journal of hazardous materials,2013,260(1):1100-1107.
13). xue, meilan,ge, yinlin*,zhang, jinyu,wang, qing,hou, lin,liu, yongchao,sun, lingling,li, quan. anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo. plos one,2012,7(8).
14) xiao zhang, yin-lin ge* and run-hua tian. the knockdown of c-myc expression by rnai inhibits cell proliferation in human colon cancer ht-29 cells in vitro and in vivo. cellular & molecular biology letters, 2009, 14(2):305-318.
15) ma, shuangshuang,ge, yinlin,gai, xiaoying,xue, meilan,li, ning,kang, jingxuan,wan, jianbo,zhang, jinyu,transgenic n-3 pufas enrichment leads to weight loss via modulating neuropeptides in hypothalamus.,neurosci lett,2016,611:28-32。
16) chen, x,ge, yl,jiang, zy,liu, cq,depoortere, i,peeters, tl,effects of ghrelin on hypothalamic glucose responding neurons in rats,brain research,2005,1055(1-2):131-136。
17) chen, zhihong,ge, yinlin,kang, jing x,down-regulation of the m6p/igf-ii receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes.,bmc cell biol,2004,5:15-15。
18) kang, z b,ge, y,chen, z,cluette-brown, j,laposata, m,leaf, a,kang, j x,adenoviral gene transfer of caenorhabditis elegans n--3 fatty acid desaturase optimizes fatty acid composition in mammalian cells.,proc natl acad sci u s a,2001,98(7):4050-4054。
获奖情况:
1). 葛银林(1/5),提高胞内w-3 不饱和脂肪酸水平抗乳腺癌研究,山东省科技厅,科技进步三等奖,2011年
2). 葛银林(1/5),化学修饰的小干扰rna抗癌研究,青岛市科技局,自然科学,三等奖,2011年
3).葛银林1/6,腺病毒介导的fat-1基因抗乳腺癌研究,2006-11, 教育厅一等奖自然科学
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