李琦,青岛大学基础医学院医学药理学系,讲师
个人简介
2021年8月 青岛大学 讲师
2016年9月-2021年7月 中国药科大学 硕博连读
2012年9月-2016年6月 中国药科大学 本科
主要研究方向
神经退行性疾病,小分子药物开发
代表性科研成果(*为通讯作者)
1. xiong b, wang y, chen y, xing s, liao q, chen y, li q*, li w*, sun h*. strategies for structural modification of small molecules to improve blood-brain barrier penetration: a recent perspective [j]. j med chem, 10.1021/acs.jmedchem.1c00910.
2. li q, chen y, xing s, liao q, xiong b, wang y, lu w, he s, feng f, liu w*, chen y*, sun h*. highly potent and selective butyrylcholinesterase inhibitors for cognitive improvement and neuroprotection [j]. j med chem, 2021, 10.1021/acs.jmedchem.1c00167.
3. li q, xing s, chen y, liao q, xiong b, he s, lu w, liu y, yang h, li q, feng f, liu w, chen y*, sun h*. discovery and biological evaluation of a novel highly potent selective butyrylcholinsterase inhibitor [j]. j med chem, 2020, 63(17): 10030-10044.
4. li q, xing s, chen y, liao q, li q, liu y, he s, feng f, chen y, zhang j, liu w, guo q, sun y, sun h*. reasonably activating nrf2: a long-term, effective and controllable strategy for neurodegenerative diseases [j]. eur j med chem, 2020, 185: 111862.
5. li q, he s, chen y, feng f, qu w, sun h*. donepezil-based multi-functional cholinesterase inhibitors for treatment of alzheimer's disease [j]. eur j med chem, 2018, 158: 463-477.
6. li q, yang h, chen y, sun h*. recent progress in the identification of selective butyrylcholinesterase inhibitors for alzheimer's disease [j]. eur j med chem, 2017, 132: 294-309.
7. li q, yang h, mo j, chen y, wu y, kang c, sun y, sun h*. identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors [j]. peerj, 2018, 6: e4206.
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