主要学术成果 科研项目： 主持和参与国家自然科学基金3项，完成科技部863重大项目子课题及科技部支撑计划各1项；山东省自然科学基金、山东省、青岛市科技攻关项目各1项；承担青岛市重大创新项目1项；研究成果获山东省自然科学二等奖；参与产学研开发项目--海生素肠溶胶囊的研发，已获临床制剂批号，研究成果获得国家发明专利3项。 著作教材： 编写研究生课程《海洋药用资源》。 期刊论文： 近年来共发表sci收录论文80余篇。 近五年代表性科研成果： 1.wenwen zhao, xi zeng, fancheng meng, xiaolin bi, dahai xu, xiuping chen, qiu li, yantao han. structural characterization and in vitro-vivo evaluation of a polysaccharide from sanguisorba officinalis on acute kidney injury.10(11), september 2019 (通讯) 2.wenwen zhao,yuan yuan, haiyu zhao, yantao han, xiuping chen. aqueous extract of salvia miltiorrhiza bunge-radix puerariae herb pair ameliorates diabetic vascular injury by inhibiting oxidative stress in streptozotocin-induced diabetic rats. 129:97-107, july2019 (通讯) 3. yanan wang, xuehong chen, xiaolin bi, yining ren, qi han, yu zhou, yantao han, ruyong yao, shangyong li. characterization of an alkaline alginate lyase with ph-stable and thermo-tolerance property.17(5):308, may 2019（通讯） 4. shangyong li, linna wang, xuehong chen, mi sun, yantao han. design and synthesis of a chitodisaccharide-based affinity resin for chitosanases purification.17(1):68 january 2019 (通讯) 5. yu zhou, xuehong chen, xiao li ,yantao han, yanan wang , ruyong yao and shangyong li. purification and characterization of a new cold-adapted and thermo-tolerant chitosanase from marine bacterium pseudoalteromonas sp. sy39 24(1):183, january2019 (通讯) 6. shangyong li, linna wang , xuehong chen, wenwen zhao, mi sun, yantao han. cloning, expression, and biochemical characterization of two new oligoalginate lyases with synergistic degradation capability. 20（1):1-12 january2018 (通讯) 7.wenwen zhao,haitao feng,shuhui guo,yantao han,xiuping chen, danshenol a inhibits tnf-α-induced expression of intercellular adhesion molecule-1 (icam-1) mediated by nox4 in endothelial cells. 7(1), december 2017 (通讯) 8.yantao han, xuehong chen, hui gao, junli ye, chunbo wang. physcion inhibits the metastatic potential of human colorectal cancer sw620 cells in vitro by suppressing the transcription factor sox2, acta pharmacol sin, 2016.2.1, 37(2): 264~275 (esi高被引) 9. gao mq, gao h, han m, liu kl, peng jj, han yt. hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat, am j cancer res, 2017.7.1, 7(7): 1501~1514 (通讯) 获奖情况： 承担青岛市重大创新项目1项，研究成果获山东省自然科学二等奖； 带领本科生斩获第十六届、第十七届“挑战杯”山东省大学收课外学术科技作品竞赛国家三等奖、山东省特等奖。 |
