主要学术成果 科研项目: 1.去泛素化酶otud3参与帕金森病黑质多巴胺能神经元死亡的分子机制研究,山东省自然科学基金重大基础研究项目,zr2019zd31,2019.12-2024.12,177万 2.铁调节蛋白irp2的去泛素化酶鉴定及其在帕金森病黑质铁聚集中的作用研究,国家自然科学基金面上项目,31771110,2018.01-2021.12,63万 3.帕金森病(pd)的早期诊断新技术研发,科技部,2016yfc1306501,2016.09 -2020.12,30万 著作教材: 1.《人体功能学》,人民卫生出版社,副主编,2020年 2.国家医学数字教材全国高等学校五年制本科临床医学专业国家卫生计生委“十二五”规划数字教材《生理学》,人民卫生出版社,参编,2016年 3.《brain iron metabolism and cns diseases》,springer出版社,参编,2019年 4.《biometals in neurodegenerative diseases: mechanisms and therapeutics》,elsevier出版社,参编,2017年 期刊论文: jiao l, du x, jia f, li y, zhu d, tang t, jiao q*, jiang h*. early low-dose ghrelin intervention via miniosmotic pumps could protect against the progressive dopaminergic neuron loss in parkinson's disease mice. neurobiology of aging, 2021, 101: 70-78. bi m, du x, jiao q, chen xi, jiang h*. expanding the role of proteasome homeostasis in parkinson’s disease: beyond protein breakdown. cell death dis. 2021 feb 4;12(2):154. xiao x#, bi m#, jiao q, chen x, du x*, jiang h*. a new understanding of ghsr1a-independent of ghrelin activation. ageing research reviews, 2020, 64: 101187. zhang p, chen l, zhao q, du x, bi m, li y, jiao q*, jiang h*. ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in parkinson's disease.free radic biol med. 2020 may 20; 152: 227-23. song n#, wang w#, jia f, du x, xie a, he q, shen x, zhang j, jt roger, xie j, jiang h*. assessments of plasma ghrelin levels in the early stages of parkinson's disease. mov disord, 2017 oct; 32(10):1487-1491. jiao q#, du x#, li y, gong b, shi l, tang t, jiang h*. the neurological effects of ghrelin in brain diseases: beyond metabolic functions. neurosci biobehav rev, 2017, 73:98-111. yu x#, du t#, song n, he q, shen y, jiang h*, xie j*. decreased iron levels in the temporal cortex in postmortem human brains with parkinson’s disease. neurology, 2013, 29; 80(5):492-5. shi l#, bian x#, qu z, ma z, zhou y, wang k*, jiang h*, xie j*. peptide hormone ghrelin enhances neuronal excitability by inhibition of kv7/kcnq channels. nat commun, 2013, 5; 4:1435. jiang h, he p, charles h. adler, holly s, thomas g. beach, li r, shen y*. bid signal pathway components are identified in the temporal cortex with parkinson disease. neurology, 2012, 79(17): 1767-73. jiang h*, song n, xu h, zhang s, wang j, xie j*. up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is ire/irp dependent. cell res, 2010, 20(3):345-56. 获奖情况: 1.基础—临床相结合协同创新的学术兼应用型研究人才培养模式的探索,山东省省级教学成果奖一等奖,第一位,2018年 2.脑肠肽ghrelin与帕金森病发生发展的关系及在帕金森病早期诊断中的应用,山东省科学技术进步奖二等奖,第一位,2020年 3.脑肠肽ghrelin与帕金森病发生发展的关系及在帕金森病早期诊断中的应用,青岛市科学技术进步奖一等奖,第一位,2019年 |