主要学术成果 科研项目： 2,3-吲哚-二酮抗神经母瘤细胞作用的靶点研究，侯琳，曹奕，张丽等。山东省重点研发项目，经费：15万元，编号：2019gsf107025,20190101-20210101； 天然活性分子isatin抗神经母细胞瘤转移的作用及分子机制研究，侯琳，鹿洪亭，张丽等。青岛大学医学部“临床医学 x”面上项目，经费：5万元，201707-201906； 天然活性分子isatin抗神经母细胞瘤转移的作用及分子机制研究，侯琳，鹿洪亭，薛美兰等。国家自然科学基金委（国家自然科学基金面上项目），项目批准号：81472542，201501-201812，经费：70万元； mirna-smart自体干细胞治疗糖尿病性缺血性心脏病，张春祥，侯琳等。青岛创业创新领军人才计划，项目编号：13-cx-3，201409-201709，经费：400万元； 著作教材： 《内分泌系统与疾病》 副主编 人民卫生出版社 国家规划教材 期刊论文： chen weiming, hao xiwe, yang binyi, zhang yuezhen, sun lingyun, hua yanan, yang li, yu jiabin, zhao jing, hou lin*, lu, hongting*. mycn-amplified neuroblastoma cell-derived exosomal mir-17-5p promotes proliferation and migration of non-mycn amplified cells.molecular medicine reports. 2021 apr, 23(4),文献号: 245. doi: 10.3892/mmr.2021.11884. hua yanan, song jinlian, peng cuixiu, wang runze, ma zhongliang, zhang jinyu, zhang zheng, li ning, hou lin.*.frontiers in cell and developmental biology. 2021 feb,文献号: 620925. liao zhaozhong, wang bin, liu wenjing, xu qian, hou lin, song jinlian, guo qingming, li ning. dysfunction of chaperone-mediated autophagy in human diseases. molecular and cellular biochemistry. 2021 mar, 476:(3): 1439-1454.2. hua yanan, zhou na, zhang jinyu, zhang zheng, li ning, wang jun, zheng wenxiang, li xue,wang fangling, zhang li, hou lin.*isatin inhibits the invasion and metastasis of sh-sy5y neuroblastoma cells in vitro and in vivo. international journal of oncology. 2021 jan, 58(1): 122-132. yang jiejie, wang bin, xu qian, yang yuling, hou lin, yin kan, guo qingming, hua yanan, zhang li, li yixuan, zhang jinyu,, li ning*.tmem166 inhibits cell proliferation, migration and invasion in hepatocellular carcinoma via upregulating tp53. molecular and cellular biochemistry. 2021 feb, 476(2):1151-1163.4. xu yang, li renpeng, li xiaoxia, dong naijun, wu di, hou lin, yin kan, zhaochunhua.an autophagy-related gene signature associated with clinical prognosis and immune microenvironment in gliomas. frontiers in oncology. 2020 oct,卷: 10,文献号: 571189. doi: 10.3389/fonc.2020.571189. dong yuan, li shuoshuo, lu yiming, li xiaoheng, liaomyajin, peng zhixin, li yunfeng, hou lin*, yuan zengqiang*,cheng jinbo.*stress-induced nlrp3 inflammasome activation negatively regulates fear memory in mice. journal of neuroinflammation. 2020 jul, 17(1),文献号: 205,doi: 10.1186/s12974-020-01842-0. wang jing, liu jin, wang yao, cao ji, hou lin, et al. smart sensing of cu(2 )in living cells by water-soluble and nontoxic tb3 /eu3 -induced aggregates of polysaccharides through fluorescence imaging. journal of materials chemistry c. 2020 dec, 8(24): 8171-8182. guo qingming, zhaopeng, zhang zhen, zhang jinyu, zhang zhen, hua yanan, han bin, li ning, zhaoxiaowen, hou, lin*.tim-3 blockade combined with bispecific antibody mt110 enhances the anti-tumor effect of gamma delta t cells. cancer immunology immunotherapy. 2020 dec, 69(12): 2571-2587. zhang lu, zhao fei, yang cuncun, tang qian, zhang ru, li jing, chen aiping, hou lin*, liu shiguo*.hypomethylation of ctgf promoter in placenta and peripheral blood of pre-eclampsia women.reproductive sciences. 2020 feb, 27(2): 468-476. xue meilan, liang hui*, ji xinqiang, liuying, ge yinlin, hou lin, sun ting.fucoidan prevent murine autoimmune diabetes via suppression tlr4-signaling pathways, regulation dc/treg induced immune tolerance and improving gut microecology. nutrition & metabolism. 2019 dec, 16(1),文献号: 87, doi: 10.1186/s12986-019-0392-1. sun teng, ding wei, xu tao), ao xiang, yu tao, li mengyang, liu ying, zhang xuejuan, hou lin, wang jianxun*.parkin regulates programmed necrosis and myocardial ischemia/reperfusion injury by targeting cyclophilin-d. antioxidants & redox signaling. 2019 dec, 31(16): 1177-1193. zhang l, sun w, cao y, hou l*, ju c, wang x. isatin inhibits the invasion of human neuroblastoma sh sy5y cells, based on microarray analysis. mol med rep. 2019 aug; 20(2):1700-1706. wang l, zhang z*, hou l*, wang y, zuo j, xue m, li x, liu y, song j, pan f, pu t. phytic acid attenuates upregulation of gsk-3β and disturbance of synaptic vesicle recycling in mptp-induced parkinson's disease models. neurochem int. 2019 jul 17;129:104507. yuandong, xiaohengli, jinbocheng, hou l*.drug development for alzheimer’s disease: microglia induced neuroinflammation as a target? int j mol sci. 2019, 20, 558; doi:10.3390/ijms20030558. shaobo cong, , haoyue luo, xue li, fangling wang, yanan hua, li zhang, zheng zhang, ning li, hou l*. isatin inhibits sh-sy5y neuroblastoma cell invasion and metastasis through pten signaling. int j clin exp pathol 2019;12(7):2446-2454. hua yn, song jl, ma zl, wu l, zhang z, zhang l, li n, cong sb, hou l*. effect of rrs1 gene knockdown on bt549 cell line proliferation and apoptosis in breast cancer. neoplasma. 2019 jan 15;66(1):28-32. song j, ma z, hua y, xu j, li n, ju c, hou l*. functional role of rrs1 in breast cancer cell proliferation. j cell mol med. 2018 dec;22(12):6304-6313. yan, peipei, tang, jianguo, zhang, yu, shen, wenfei, wang, yao, hou, lin, et al. spr-enhanced fluorescence and protein-improved blood compatibility of quadruple core/shell nanostructure of ag@sio2@eu3 (tta)(3)phen@protein. micro & nano letters. 2018 oct, 13(10):1447-1452.. li mengyang, ding wei, tariq muhammad akram, chang wenguang, zhang xuejuan, xu wenhua, hou lin, wang yifei,wang jianxun*.a circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting mir-133a-3p. theranostics. 2018, 8(21): 5855-5869. ju c, gao j,hou l*, wang l, zhang f, sun f, zhang t, xu p, shi z, hu f, zhang c. neuroprotective effect of chondroitin sulfate on sh‑sy5y cells overexpressing wild‑type or a53t mutant alpha‑synuclein. mol med rep. 2017 dec;16(6):8721-8728.2. wang weijing, jiang wenjie, hou lin, duan haiping,wu yili, xu chunsheng, tan qihua, li shuxia, zhang dongfeng*.weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to bmi. bmc genomics. 2017 nov,卷: 18,文献号: 872, doi: 10.1186/s12864-017-4257-6. sun w, zhang l, hou l*, ju c, zhao s, wei y.isatin inhibits sh-sy5y neuroblastoma cell invasion and metastasis through mao/hif-1α/cxcr4 signaling.anticancer drugs. 2017 jul;28(6):645-653. wang y, wang y, jia s, dong q, chen y, lu s, hou l*. effect of lipid-bound apolipoprotein a-i cysteine mutant on atf3 in raw264.7 cells.biosci rep. 2017 feb 28; 37(1): bsr20160398. cao y, hou l*, wang w. dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: a meta-analysis of prospective cohort studies. int j cancer. 2016 apr 15;138(8):1894-904. doi: 10.1002/ijc.29938. zhang z, hou l*, song jl, song n, sun yj, lin x, wang xl, zhang fz, ge yl. pro-inflammatory cytokine-mediated ferroportin down-regulation contributes to the nigral iron accumulation in lipopolysaccharide-induced parkinsonian models. neuroscience. 2014, 257:20-30. song j, hou l*, ju c, zhang j, ge y, yue w. isatin inhibits proliferation and induces apoptosis of sh-sy5y neuroblastoma cells in vitro and in vivo. eur j pharmacol. 2013, 702(1-3):235-241. hou l, ju c, zhang j, song j, ge y, yue w. antitumor effects of isatin on human neuroblastoma cell line (sh-sy5y) and the related mechanism. eur j pharmacol. 2008 jul 28;589(1-3):27-31. 29. fan xu, lu hongting, hou lin, zhang li, yang bin yi, chen wei ming, zhang huan-yu; chen xin, li fu-jiang. chinese journal of contemporary pediatrics(中国当代儿科杂志）.2020 mar, 22(3): 262-268. 30.徐倩,许银丰,杨杰杰,王彬,侯琳,李宁.内质网应激与细胞自噬的关系.中国细胞生物学学报. 2020, 42(8): 1489-1500. 31.张莹,孔祥熙,侯琳,王树坤,袁增强.ozanimod( rpc1063)在少突胶质前体细胞分化中的作用和机制.中国生物工程杂志. 2020, 40(6): 10-19. 32..王慧,史婉婷,杨杰杰,王彬, 侯琳,李宁.从干扰素诱导蛋白mxa筛选抗乙肝病毒活性肽.中国生物化学与分子生物学报. 2019, 35(7): 739-748. 33.华亚男,牟文凤,宋金莲,许军婷,侯琳*.沉默rrs 1基因表达对乳腺癌bt549细胞生物学功能的影响.肿瘤, 2018,28(1):35-43. 34.董渊，李晓恒，侯琳，程金波。先天免疫受体介导的神经炎症在神经系统疾病中的作用[j]，中国药理学与毒理学杂志，2017,31(11):1075-1083. 获奖情况： 1.帕金森氏病发病机制和营养干预研究，山东省医学科技三等奖，首位，2017年； 2.帕金森氏病发病机制和营养干预研究，青岛市科技进步二等奖 首位，2018年； 3.抑癌基因甲基化和生活方式与乳腺癌发生的关系及2,3-吲哚醌干预研究，青岛市科技进步二等奖，首位，2016年； 4.乳腺癌易感/抑癌基因甲基化及2,3-吲哚醌的干预研究，山东省教育厅高校优秀科研成果一等奖，首位，2015年； |
